tem ht7700  (Hitachi Ltd)

Journal: Materials Today Bio

Article Title: Systemic Immunity Triggered by Boron Neutron Capture Therapy via Manganese-Borate Complex

doi: 10.1016/j.mtbio.2026.102904

Figure Lengend Snippet: Assembly and hydrogen peroxide-responsive release of Albumin@MnB. a, Self-assembly after coordination with different metal ions with B and 4B. b , The structural formula for B and 4B. c , Scheme of coordination self-assembly of Mn 2+ and albumin. d , Schematic illustration of the assembly principle between albumin and 4B. e , Particle size analysis of Albumin@MnB and MnB. f , Zeta potential analysis of Albumin@MnB and MnB. g , Transmission electron microscopy (TEM) image of Albumin@MnB. h , Elemental distribution in this protein formulation (Scale bars, 200 nm). i , Disassembly of different metal ions coordinated with 4B in response to H 2 O 2 . j , Particle size analysis of Albumin@MnB under H 2 O and H 2 O 2 conditions. k , TEM images of Albumin@MnB under H 2 O and H 2 O 2 conditions (Scale bars, 200 nm). l-m , Release of boron and Mn from the protein formulation at different H 2 O 2 concentrations (n=3, Data represent mean ± s.d.). o , Laser Scanning Confocal Microscopy (LSCM) images of 4T1 and 3T3 cells (Scale bars, 100 μm). p , Schematic illustration of the disassembly principle of the protein formulation under H 2 O 2 conditions.

Article Snippet: The transmission electron microscopy (TEM) images were taken on a JEOL JEM-2200FS microscope.

Techniques: Particle Size Analysis, Zeta Potential Analyzer, Transmission Assay, Electron Microscopy, Formulation, Confocal Microscopy